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The predicted binding site and dynamics of peptide inhibitors to the Methuselah GPCR from Drosophila melanogaster
Peptide inhibitors of Methuselah (Mth), a G protein-coupled receptor (GPCR), were reported that can extend the lifespan of Drosophila melanogaster. Mth is a class B GPCR, which is characterized by a large, N-terminal ectodomain that is often involved with ligand recognition. The crystal structure of...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900200/ https://ncbi.nlm.nih.gov/pubmed/18991399 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801335p |
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