A role for lipid bodies in the cross-presentation of phagocytozed antigens by MHC class I in dendritic cells

Dendritic cells (DCs) have the striking ability to cross-present exogenous antigens in association with MHC class I to CD8+ T cells. However, the intracellular pathways underlying cross-presentation remain ill-defined. Current models involve cytosolic proteolysis of antigens by the proteasome and TA...

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Autors principals: Bougneres, Laurence, Helft, Julie, Tiwari, Sangeeta, Vargas, Pablo, Chang, Benny Hung-Junn, Chan, Lawrence, Campisi, Laura, Lauvau, Gregoire, Hugues, Stephanie, Kumar, Pradeep, Kamphorst, Alice O., Dumenil, Ana-Maria Lennon, Nussenzweig, Michel, MacMicking, John D., Amigorena, Sebastian, Guermonprez, Pierre
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803012/
https://ncbi.nlm.nih.gov/pubmed/19699172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.06.022
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