Novel role of phosphorylation in Fe–S cluster stability revealed by phosphomimetic mutations at Ser-138 of iron regulatory protein 1

Animals regulate iron metabolism largely through the action of the iron regulatory proteins (IRPs). IRPs modulate mRNA utilization by binding to iron-responsive elements (IRE) in the 5′ or 3′ untranslated region of mRNAs encoding proteins involved in iron homeostasis or energy production. IRP1 is al...

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Bibliographic Details
Main Authors: Brown, Nina M., Anderson, Sheila A., Steffen, Daniel W., Carpenter, Tami B., Kennedy, M. Claire, Walden, William E., Eisenstein, Richard S.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC28026/
https://ncbi.nlm.nih.gov/pubmed/9860952
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