ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

Resistance of human cancer cells to multiple cytotoxic hydrophobic agents (multidrug resistance) is due to overexpression of the "MDR1" gene, whose product is the plasma membrane P-glycoprotein. Plasma membrane vesicles partially purified from multidrug-resistant human KB carcinoma cells, but not fr...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Horio, M, Gottesman, M M, Pastan, I
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280257/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3368466/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3580
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