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Mutations in the DnaK chaperone affecting interaction with the DnaJ cochaperone

Hsp70 chaperones assist protein folding by ATP-controlled cycles of substrate binding and release. ATP hydrolysis is the rate-limiting step of the ATPase cycle that causes locking in of substrates into the substrate-binding cavity of Hsp70. This key step is strongly stimulated by DnaJ cochaperones....

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Autori principali: Gässler, Claudia S., Buchberger, Alexander, Laufen, Thomas, Mayer, Matthias P., Schröder, Hartwig, Valencia, Alfonso, Bukau, Bernd
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC28025/
https://ncbi.nlm.nih.gov/pubmed/9860951
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