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An Epilepsy-Related Region in the GABA(A) Receptor Mediates Long-Distance Effects on GABA and Benzodiazepine Binding Sites
The GABA(A) receptor mutation γ(2)R43Q causes absence epilepsy in humans. Homology modeling suggests that γ(2)Arg43, γ(2)Glu178, and β(2)Arg117 participate in a salt-bridge network linking the γ(2) and β(2) subunits. Here we show that several mutations at these locations exert similar long-distance...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental
Therapeutics
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802431/ https://ncbi.nlm.nih.gov/pubmed/19846749 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.058289 |
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