A carregar...

An Epilepsy-Related Region in the GABA(A) Receptor Mediates Long-Distance Effects on GABA and Benzodiazepine Binding Sites

The GABA(A) receptor mutation γ(2)R43Q causes absence epilepsy in humans. Homology modeling suggests that γ(2)Arg43, γ(2)Glu178, and β(2)Arg117 participate in a salt-bridge network linking the γ(2) and β(2) subunits. Here we show that several mutations at these locations exert similar long-distance...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Goldschen-Ohm, Marcel P., Wagner, David A., Petrou, Steven, Jones, Mathew V.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802431/
https://ncbi.nlm.nih.gov/pubmed/19846749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.058289
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!