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Intestinal Detoxification Limits the Activation of Hepatic Pregnane X Receptor by Lithocholic Acid
The intestinal-derived secondary bile acid (BA) lithocholic acid (LCA) is hepatotoxic and is implicated in the pathogenesis of cholestatic diseases. LCA is an endogenous ligand of the xenobiotic nuclear receptor pregnane X receptor (PXR), but there is currently no consensus on the respective roles o...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society for Pharmacology and Experimental
Therapeutics
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2802420/ https://ncbi.nlm.nih.gov/pubmed/19797606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.029306 |
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