Roles of a 67-kDa polypeptide in reversal of protein synthesis inhibition in heme-deficient reticulocyte lysate.

During heme deficiency in reticulocyte lysates, the heme-regulated protein synthesis inhibitor, HRI, phosphorylates the alpha subunit of eukaryotic initiation factor 2 (eIF-2) and thus inhibits protein synthesis. Two factors, eIF-2 and a reticulocyte-lysate supernatant factor that we term RF, revers...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Datta, B, Chakrabarti, D, Roy, A L, Gupta, N K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1988
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280201/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3368443/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3324
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