A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody.
An autoantibody from a patient with lupus-overlap syndrome was found to bind a specific region of U1 RNA. By using RNA sequence analysis, immunoprecipitation, and competition experiments with in vitro synthesized fragments of U1 RNA, a region of 40 nucleotides representing a stem-loop secondary stru...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1988
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280196/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2453054/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3299 |
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