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A sequence-specific conformational epitope on U1 RNA is recognized by a unique autoantibody.

An autoantibody from a patient with lupus-overlap syndrome was found to bind a specific region of U1 RNA. By using RNA sequence analysis, immunoprecipitation, and competition experiments with in vitro synthesized fragments of U1 RNA, a region of 40 nucleotides representing a stem-loop secondary stru...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Deutscher, S L, Keene, J D
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280196/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2453054/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.10.3299
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