Genome-wide Association Scan Identifies Variants near Matrix Metalloproteinase (MMP) Genes on Chromosome 11q21-22 Strongly Associated with Serum MMP-1 Levels

BACKGROUND: Matrix metalloproteinase 1 (MMP-1) may play a role in cardiovascular disease (CVD) susceptibility by influencing plaque rupture via its ability to degrade extracellular collagens. METHODS AND RESULTS: We performed a genome-wide association analysis of circulating MMP-1 levels using 500K...

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Bibliografski detalji
Glavni autori: Cheng, Yu-Ching, Kao, Wen-Hong L., Mitchell, Braxton D., O’Connell, Jeffrey R., Shen, Haiqing, McArdle, Patrick F, Gibson, Quince, Ryan, Kathleen A., Shuldiner, Alan R., Pollin, Toni I.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801898/
https://ncbi.nlm.nih.gov/pubmed/20031604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCGENETICS.108.834986
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