Accounting for Relatedness in Family Based Genetic Association Studies

OBJECTIVE: Assess the differences in point estimates, power and type 1 error rates when accounting for and ignoring family structure in genetic tests of association. METHODS: We compare by simulation the performance of analytic models using variance components to account for family structure and reg...

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Main Authors: McArdle, P.F., O’Connell, J.R., Pollin, T.I., Baumgarten, M., Shuldiner, A.R., Peyser, P.A., Mitchell, B.D.
Format: Artigo
Jezik:Inglês
Izdano: S. Karger AG 2007
Teme:
Original Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2880729/
https://ncbi.nlm.nih.gov/pubmed/17570925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000103861
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