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Cyclic Nucleotide Binding GAF Domains from Phosphodiesterases – Structural and Mechanistic Insights
GAF domains regulate the catalytic activity of certain vertebrate cyclic nucleotide phosphodiesterases (PDEs) by allosteric, non-catalytic binding of cyclic nucleotides. GAF domains arranged in tandem are found in PDE2, -5, -6, 10, and -11, all of which regulate the cellular concentrations of the se...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801740/ https://ncbi.nlm.nih.gov/pubmed/20004158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.07.019 |
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