The E3 Ubiquitin Ligases Hrd1 and gp78 Bind to and Promote Cholera Toxin Retro-Translocation

To cause disease, cholera toxin (CT) is transported from the cell surface to the endoplasmic reticulum (ER) lumen where the catalytic CTA1 subunit retro-translocates to the cytosol to induce pathological water secretion. Two retro-translocon components are the Derlins and ER-associated multi-spannin...

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Main Authors: Bernardi, Kaleena M., Williams, Jeffrey M., Kikkert, Marjolein, van Voorden, Sjaak, Wiertz, Emmanuel J., Ye, Yihong, Tsai, Billy
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2010
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801707/
https://ncbi.nlm.nih.gov/pubmed/19864457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-07-0586
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