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Identifying Potent, Selective Protein Tyrosine Phosphatase Inhibitors from a Library of Au(I) Complexes
Therapeutic inhibition of protein tyrosine phosphatase activity is a compelling yet challenging approach to the treatment of human disease. Towards this end, a library of 40 gold complexes with the general formula R(3)P–Au–Cl was screened to identify novel inhibitors of PTP activity. The most promis...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801581/ https://ncbi.nlm.nih.gov/pubmed/19888762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm901220m |
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