Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2: BIOACTIVATION OF NITROGLYCERIN AND EFFECTS OF Alda-1

The East Asian variant of mitochondrial aldehyde dehydrogenase (ALDH2) exhibits significantly reduced dehydrogenase, esterase, and nitroglycerin (GTN) denitrating activities. The small molecule Alda-1 was reported to partly restore low acetaldehyde dehydrogenase activity of this variant. In the pres...

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Autori principali: Beretta, Matteo, Gorren, Antonius C. F., Wenzl, M. Verena, Weis, Robert, Russwurm, Michael, Koesling, Doris, Schmidt, Kurt, Mayer, Bernd
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Enzyme Catalysis and Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801295/
https://ncbi.nlm.nih.gov/pubmed/19906643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.014548
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