N Terminus Is Key to the Dominant Negative Suppression of Ca(V)2 Calcium Channels: IMPLICATIONS FOR EPISODIC ATAXIA TYPE 2

Expression of the calcium channels Ca(V)2.1 and Ca(V)2.2 is markedly suppressed by co-expression with truncated constructs containing Domain I. This is the basis for the phenomenon of dominant negative suppression observed for many of the episodic ataxia type 2 mutations in Ca(V)2.1 that predict tru...

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Main Authors: Page, Karen M., Heblich, Fay, Margas, Wojciech, Pratt, Wendy S., Nieto-Rostro, Manuela, Chaggar, Kanchan, Sandhu, Kieran, Davies, Anthony, Dolphin, Annette C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801285/
https://ncbi.nlm.nih.gov/pubmed/19903821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.065045
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