Distinct Roles for Rho Versus Rac/Cdc42 GTPases Downstream of Vav2 in Regulating Mammary Epithelial Acinar Architecture

Non-malignant mammary epithelial cells (MECs) undergo acinar morphogenesis in three-dimensional Matrigel culture, a trait that is lost upon oncogenic transformation. Rho GTPases are thought to play important roles in regulating epithelial cell-cell junctions, but their contributions to acinar morpho...

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Main Authors: Duan, Lei, Chen, Gengsheng, Virmani, Sumeet, Ying, GuoGuang, Raja, Srikumar M., Chung, Byung Min, Rainey, Mark A., Dimri, Manjari, Ortega-Cava, Cesar F., Zhao, Xiangshan, Clubb, Robert J., Tu, Chun, Reddi, Alagarsamy L., Naramura, Mayumi, Band, Vimla, Band, Hamid
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801280/
https://ncbi.nlm.nih.gov/pubmed/19826000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.057976
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