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MRE11-RAD50-NBS1 Complex Dictates DNA Repair Independent of H2AX
DNA double-strand breaks (DSBs) represent one of the most serious forms of DNA damage that can occur in the genome. Here, we show that the DSB-induced signaling cascade and homologous recombination (HR)-mediated DSB repair pathway can be genetically separated. We demonstrate that the MRE11-RAD50-NBS...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2801237/ https://ncbi.nlm.nih.gov/pubmed/19910469 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078436 |
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