MRE11-RAD50-NBS1 Complex Dictates DNA Repair Independent of H2AX

DNA double-strand breaks (DSBs) represent one of the most serious forms of DNA damage that can occur in the genome. Here, we show that the DSB-induced signaling cascade and homologous recombination (HR)-mediated DSB repair pathway can be genetically separated. We demonstrate that the MRE11-RAD50-NBS...

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Bibliographic Details
Main Authors: Yuan, Jingsong, Chen, Junjie
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2801237/
https://ncbi.nlm.nih.gov/pubmed/19910469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.078436
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