Frequent generation of oncogenes by in vitro recombination of TRK protooncogene sequences.

Transfection of NIH 3T3 cells with cDNA clones containing either the entire coding sequences or the tyrosine protein kinase domain of the human TRK protooncogene results in the frequent generation of transforming genes. Activation of most of these TRK oncogenes involves acquisition of DNA sequences....

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Bibliographic Details
Main Authors: Oskam, R, Coulier, F, Ernst, M, Martin-Zanca, D, Barbacid, M
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC280123/
https://ncbi.nlm.nih.gov/pubmed/3362859
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