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Disrupting the Rb-Raf-1 Interaction: A potential therapeutic target for cancer
Cell cycle progression in cancer is often mediated by disrupting the function of the retinoblastoma tumor suppressor protein, Rb. One way in which Rb’s function is altered is through phosphorylation mediated by cyclin dependent kinases (1). Our studies had shown that the Raf-1 kinase binds and phosp...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2800199/ https://ncbi.nlm.nih.gov/pubmed/18836591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1358/dnp.2008.21.6.1246832 |
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