Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine

Metastatic melanoma is an aggressive cancer with very low response rate against conventional chemotherapeutic agents such as dacarbazine (DTIC). Inhibitor of Rb-Raf-1 interaction (RRD-251) was tested against the melanoma cell lines SK-MEL-28, SK-MEL-5 and SK-MEL-2. RRD-251 was found to be a potent i...

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Detalhes bibliográficos
Main Authors: Singh, Sandeep, Davis, Rebecca, Alamanda, Vignesh, Pireddu, Roberta, Pernazza, Daniel, Sebti, Said, Lawrence, Nicholas, Chellappan, Srikumar
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058238/
https://ncbi.nlm.nih.gov/pubmed/21139044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0442
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