Disruption of the Rb-Raf-1 Interaction Inhibits Tumor Growth and Angiogenesis

The retinoblastoma tumor suppressor protein (Rb) plays a vital role in regulating mammalian cell cycle progression and inactivation of Rb is necessary for entry into S phase. Rb is inactivated by phosphorylation upon growth factor stimulation of quiescent cells, facilitating the transition from G(1)...

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Main Authors: Dasgupta, Piyali, Sun, Jiazhi, Wang, Sheng, Fusaro, Gina, Betts, Vicki, Padmanabhan, Jaya, Sebti, Saïd M., Chellappan, Srikumar P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC522224/
https://ncbi.nlm.nih.gov/pubmed/15485920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9527-9541.2004
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