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Disruption of the Rb-Raf-1 Interaction Inhibits Tumor Growth and Angiogenesis
The retinoblastoma tumor suppressor protein (Rb) plays a vital role in regulating mammalian cell cycle progression and inactivation of Rb is necessary for entry into S phase. Rb is inactivated by phosphorylation upon growth factor stimulation of quiescent cells, facilitating the transition from G(1)...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522224/ https://ncbi.nlm.nih.gov/pubmed/15485920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9527-9541.2004 |
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