Sequence-specific recognition and cleavage of DNA by metallobleomycin: minor groove binding and possible interaction mode.
The DNase I cleavage-inhibition analysis shows binding sites of approximately 2 or 3 base pairs--in particular, 5' N-G-C sequences--for the green-colored CoIII and fully oxidized FeIII complexes of bleomycin. The apparent binding constant of the bleomycin-CoIII complex is quite similar for glucosyla...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1988
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC280016/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2451823/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.8.2459 |
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