Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo

Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/β-catenin pathway, we challenged the allele combinations by genetically restricting intracel...

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Main Authors: Buchert, Michael, Athineos, Dimitris, Abud, Helen E., Burke, Zoe D., Faux, Maree C., Samuel, Michael S., Jarnicki, Andrew G., Winbanks, Catherine E., Newton, Ian P., Meniel, Valerie S., Suzuki, Hiromu, Stacker, Steven A., Näthke, Inke S., Tosh, David, Huelsken, Joerg, Clarke, Alan R., Heath, Joan K., Sansom, Owen J., Ernst, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2800045/
https://ncbi.nlm.nih.gov/pubmed/20084116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000816
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