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The induction of folding cooperativity by ligand binding drives the allosteric response of tetracycline repressor
Tetracycline (Tc) repressor (TetR) undergoes an allosteric transition upon interaction with the antibiotic, Tc, that abrogates its ability to specifically bind its operator DNA. In this work, by performing equilibrium protein unfolding experiments on wild-type TetR and mutants displaying altered all...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799725/ https://ncbi.nlm.nih.gov/pubmed/20080791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911566106 |
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