Загрузка...
The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped Topoisomerase II-DNA cleavable complexes
Type II topoisomerases (TOP2) introduce transient double-stranded DNA breaks through a covalent TOP2-DNA intermediate. Anticancer agents like etoposide kill cells by trapping covalent TOP2-DNA cleavable complexes. Pathways influencing the repair of cleavable complexes are expected to be major determ...
Сохранить в:
| Главные авторы: | , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2005
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799250/ https://ncbi.nlm.nih.gov/pubmed/16091739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1208958 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|