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The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped Topoisomerase II-DNA cleavable complexes
Type II topoisomerases (TOP2) introduce transient double-stranded DNA breaks through a covalent TOP2-DNA intermediate. Anticancer agents like etoposide kill cells by trapping covalent TOP2-DNA cleavable complexes. Pathways influencing the repair of cleavable complexes are expected to be major determ...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2799250/ https://ncbi.nlm.nih.gov/pubmed/16091739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1208958 |
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