Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli.

A cDNA clone for human interleukin 2 (IL-2) has been fused to the 5' end of a modified Pseudomonas exotoxin (PE) gene that lacks the sequences encoding the cell recognition domain. The chimeric protein IL-2-PE40 was produced in Escherichia coli. It was extremely toxic to IL-2 receptor-positive cells...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Lorberboum-Galski, H, FitzGerald, D, Chaudhary, V, Adhya, S, Pastan, I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279893/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3126499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.6.1922
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