Comprehensive genomic screens identify a role for PLZF-RARα as a positive regulator of cell proliferation via direct regulation of c-MYC

The t(11;17)(q23;q21) translocation is associated with a retinoic acid (RA)–insensitive form of acute promyelocytic leukemia (APL), involving the production of reciprocal fusion proteins, promyelocytic leukemia zinc finger–retinoic acid receptor α (PLZF-RARα) and RARα-PLZF. Using a combination of ch...

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Detalhes bibliográficos
Main Authors: Rice, Kim L., Hormaeche, Itsaso, Doulatov, Sergei, Flatow, Jared M., Grimwade, David, Mills, Ken I., Leiva, Magdalena, Ablain, Julien, Ambardekar, Charuta, McConnell, Melanie J., Dick, John E., Licht, Jonathan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798864/
https://ncbi.nlm.nih.gov/pubmed/19855079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-206524
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