Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts

Atrial fibrillation (AF) is a common arrhythmia that increases the risk of stroke and heart failure. Here, we have shown that mast cells, key mediators of allergic and immune responses, are critically involved in AF pathogenesis in stressed mouse hearts. Pressure overload induced mast cell infiltrat...

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Detalhes bibliográficos
Main Authors: Liao, Chien-hui, Akazawa, Hiroshi, Tamagawa, Masaji, Ito, Kaoru, Yasuda, Noritaka, Kudo, Yoko, Yamamoto, Rie, Ozasa, Yukako, Fujimoto, Masanori, Wang, Ping, Nakauchi, Hiromitsu, Nakaya, Haruaki, Komuro, Issei
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798688/
https://ncbi.nlm.nih.gov/pubmed/20038802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39942
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