In Vitro and In Vivo Activities of 1-Hydroxy-2-Alkyl-4(1H)Quinolone Derivatives against Toxoplasma gondii

1-Hydroxy-2-dodecyl-4(1H)quinolone (HDQ) was recently identified as a Toxoplasma gondii inhibitor. We describe here two novel 1-hydroxyquinolones, which displayed 50% inhibitory concentrations 10- and 5-fold lower than that of HDQ. In a mouse model of acute toxoplasmosis, these two compounds and HDQ...

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Hlavní autoři: Bajohr, Lara Liv, Ma, Ling, Platte, Christian, Liesenfeld, Oliver, Tietze, Lutz F., Groß, Uwe, Bohne, Wolfgang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2010
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798484/
https://ncbi.nlm.nih.gov/pubmed/19884369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01001-09
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