Hepatitis C Virus-Linked Mitochondrial Dysfunction Promotes Hypoxia-Inducible Factor 1α-Mediated Glycolytic Adaptation

Hepatitis C virus (HCV) infection induces a state of oxidative stress by affecting mitochondrial-respiratory-chain activity. By using cell lines inducibly expressing different HCV constructs, we showed previously that viral-protein expression leads to severe impairment of mitochondrial oxidative pho...

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Detalhes bibliográficos
Main Authors: Ripoli, Maria, D'Aprile, Annamaria, Quarato, Giovanni, Sarasin-Filipowicz, Magdalena, Gouttenoire, Jérôme, Scrima, Rosella, Cela, Olga, Boffoli, Domenico, Heim, Markus H., Moradpour, Darius, Capitanio, Nazzareno, Piccoli, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Cellular Response to Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798449/
https://ncbi.nlm.nih.gov/pubmed/19846525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00769-09
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