MDA5 and MAVS Mediate Type I Interferon Responses to Coxsackie B Virus

Coxsackie B viruses (CVB) are enteroviruses that have been associated with a variety of human diseases, including myocarditis. In the present study, we found that MDA5 and its adaptor molecule MAVS are critical for type I interferon responses to CVB, since the absence of either MAVS or MDA5 leads to...

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Bibliographic Details
Main Authors: Wang, Jennifer P., Cerny, Anna, Asher, Damon R., Kurt-Jones, Evelyn A., Bronson, Roderick T., Finberg, Robert W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798442/
https://ncbi.nlm.nih.gov/pubmed/19846534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00631-09
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