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Site-Specific Phosphorylation Induces Functionally Active Conformation in the Intrinsically Disordered N-Terminal Activation Function (AF1) Domain of the Glucocorticoid Receptor

Intrinsically disordered (ID) regions are disproportionately higher in cell signaling proteins and are predicted to have much larger frequency of phosphorylation sites than ordered regions, suggesting an important role in their regulatory capacity. In this study, we show that AF1, an ID activation d...

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Autors principals: Garza, Anna M. S., Khan, Shagufta H., Kumar, Raj
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798295/
https://ncbi.nlm.nih.gov/pubmed/19841061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00552-09
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