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Competition between the RNA Transcript and the Nontemplate DNA Strand during R-Loop Formation In Vitro: a Nick Can Serve as a Strong R-Loop Initiation Site

Upon transcription of some sequences by RNA polymerases in vitro or in vivo, the RNA transcript can thread back onto the template DNA strand, resulting in an R loop. Previously, we showed that initiation of R-loop formation at an R-loop initiation zone (RIZ) is favored by G clusters. Here, using a p...

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Autors principals: Roy, Deepankar, Zhang, Zheng, Lu, Zhengfei, Hsieh, Chih-Lin, Lieber, Michael R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798282/
https://ncbi.nlm.nih.gov/pubmed/19841062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00897-09
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