Prime-Boost Immunization with Adenoviral and Modified Vaccinia Virus Ankara Vectors Enhances the Durability and Polyfunctionality of Protective Malaria CD8(+) T-Cell Responses

Protection against liver-stage malaria relies on the induction of high frequencies of antigen-specific CD8(+) T cells. We have previously reported high protective levels against mouse malaria, albeit short-lived, by a single vaccination with adenoviral vectors coding for a liver-stage antigen (ME.TR...

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Main Authors: Reyes-Sandoval, Arturo, Berthoud, Tamara, Alder, Nicola, Siani, Loredana, Gilbert, Sarah C., Nicosia, Alfredo, Colloca, Stefano, Cortese, Riccardo, Hill, Adrian V. S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2010
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798185/
https://ncbi.nlm.nih.gov/pubmed/19858306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00740-09
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