Tetracycline Treatment Retards the Onset and Slows the Progression of Diabetes in Human Amylin/Islet Amyloid Polypeptide Transgenic Mice

OBJECTIVE: Aggregation of human amylin/islet amyloid polypeptide (hA/hIAPP) into small soluble β-sheet–containing oligomers is linked to islet β-cell degeneration and the pathogenesis of type 2 diabetes. Here, we used tetracycline, which modifies hA/hIAPP oligomerization, to probe mechanisms whereby...

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Autori principali: Aitken, Jacqueline F., Loomes, Kerry M., Scott, David W., Reddy, Shivanand, Phillips, Anthony R.J., Prijic, Gordana, Fernando, Chathurini, Zhang, Shaoping, Broadhurst, Ric, L'Huillier, Phil, Cooper, Garth J.S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2010
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797917/
https://ncbi.nlm.nih.gov/pubmed/19794060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0548
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