Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D.
The activity of the endogenous DNA topoisomerase type I (EC 5.99.1.2) can be quantified in situ by determining how efficiently the enzyme is trapped in a covalent complex with DNA upon lysis of nuclei with detergents. In this way, we can measure relative levels of topoisomerase binding to DNA at nat...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1988
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279782/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2830618/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.5.1417 |
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