Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D.
The activity of the endogenous DNA topoisomerase type I (EC 5.99.1.2) can be quantified in situ by determining how efficiently the enzyme is trapped in a covalent complex with DNA upon lysis of nuclei with detergents. In this way, we can measure relative levels of topoisomerase binding to DNA at nat...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
1988
|
| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279782/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2830618/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.5.1417 |
| Tagit: |
Ei tageja, Lisää ensimmäinen tagi!
|