New Arylthioindoles and Related Bioisosteres at the Sulfur Bridging Group. 4. Synthesis, Tubulin Polymerization, Cell Growth Inhibition, and Molecular Modeling Studies

New arylthioindoles along with the corresponding ketone and methylene compounds were potent tubulin assembly inhibitors. As growth inhibitors of MCF-7 cells, sulfur derivatives were superior or sometimes equivalent to the ketones, while methylene derivatives were substantially less effective. Esters...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: La Regina, Giuseppe, Sarkar, Taradas, Bai, Ruoli, Edler, Michael C., Saletti, Roberto, Coluccia, Antonio, Piscitelli, Francesco, Minelli, Lara, Gatti, Valerio, Mazzoccoli, Carmela, Palermo, Vanessa, Mazzoni, Cristina, Falcone, Claudio, Scovassi, Anna Ivana, Giansanti, Vincenzo, Campiglia, Pietro, Porta, Amalia, Maresca, Bruno, Hamel, Ernest, Brancale, Andrea, Novellino, Ettore, Silvestri, Romano
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797757/
https://ncbi.nlm.nih.gov/pubmed/19601594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900016t
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares