Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.

Whole-cell and single-channel recording techniques were used to study the action of the anticonvulsant drug MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine maleate) on responses to excitatory amino acids in rat neocortical neurons in cell culture. MK-801 caused a progressi...

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Main Authors: Huettner, J E, Bean, B P
Formato: Artigo
Idioma:Inglês
Publicado: 1988
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC279756/
https://ncbi.nlm.nih.gov/pubmed/2448800
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