The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

The compound MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d] cyclohepten-5,10-imine maleate)] is a potent anticonvulsant that is active after oral administration and whose mechanism of action is unknown. We have detected high-affinity (Kd = 37.2 +/- 2.7 nM) binding sites for [3H]MK-801 in rat bra...

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Main Authors: Wong, E H, Kemp, J A, Priestley, T, Knight, A R, Woodruff, G N, Iversen, L L
格式: Artigo
語言:Inglês
出版: 1986
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC386661/
https://ncbi.nlm.nih.gov/pubmed/3529096
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