Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: selective binding to open channels.
Whole-cell and single-channel recording techniques were used to study the action of the anticonvulsant drug MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]- cyclohepten-5,10-imine maleate) on responses to excitatory amino acids in rat neocortical neurons in cell culture. MK-801 caused a progressi...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1988
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279756/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2448800/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.4.1307 |
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