Identification of HLA class II-restricted determinants of Mycobacterium tuberculosis-derived proteins by using HLA-transgenic, class II-deficient mice

T helper 1 cells play a major role in protective immunity against mycobacterial pathogens. Since the antigen (Ag) specificity of CD4(+) human T cells is strongly controlled by HLA class II polymorphism, the immunogenic potential of candidate Ags needs to be defined in the context of HLA polymorphism...

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Detalhes bibliográficos
Main Authors: Geluk, Annemieke, Taneja, Veena, van Meijgaarden, Krista E., Zanelli, Eric, Abou-Zeid, Christiane, Thole, Jelle E. R., de Vries, René R. P., David, Chella S., Ottenhoff, Tom H. M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27975/
https://ncbi.nlm.nih.gov/pubmed/9724784
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