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Mapping of multiple HLA class II-restricted T-cell epitopes of the mycobacterial 70-kilodalton heat shock protein.

By combining a DNA subclone and synthetic-peptide approach, we mapped epitopes of the immunogenic mycobacterial 70-kDa heat shock protein (HSP70) recognized by human CD4+ T-cell clones and lines. In addition, we identified the respective HLA-DR molecules used in antigen presentation. The donor group...

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Autori principali: Oftung, F, Geluk, A, Lundin, K E, Meloen, R H, Thole, J E, Mustafa, A S, Ottenhoff, T H
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1994
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC303282/
https://ncbi.nlm.nih.gov/pubmed/7525484
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