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Pumiliotoxin B binds to a site on the voltage-dependent sodium channel that is allosterically coupled to other binding sites.

Pumiliotoxin B (PTX-B), an alkaloid that has cardiotonic and myotonic activity, increases sodium influx in guinea pig cerebral cortical synaptoneurosomes. In the presence of scorpion venom (Leiurus) or purified alpha-scorpion toxin, the PTX-B-induced sodium influx is enhanced severalfold. PTX-B alon...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gusovsky, F, Rossignol, D P, McNeal, E T, Daly, J W
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279749/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2448797/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.4.1272
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