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The ion selectivity filter is not an activation gate in TRPV1-3 channels

Activation of TRPV1 channels in sensory neurons results in opening of a cation permeation pathway that triggers the sensation of pain. Opening of TRPV1 has been proposed to involve two gates that appear to prevent ion permeation in the absence of activators: the ion selectivity filter on the externa...

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Principais autores: Andrés Jara-Oseguera, Katherine E Huffer, Kenton J Swartz
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications Ltd 2019-11-01
סדרה:eLife
נושאים:
TRP channel
TRPV3
ion channel gating
TRPV2
activation gate
גישה מקוונת:https://elifesciences.org/articles/51212
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