MicroRNA-122 Inhibits Tumorigenic Properties of Hepatocellular Carcinoma Cells and Sensitizes These Cells to Sorafenib

MicroRNAs are negative regulators of protein coding genes. The liver-specific microRNA-122 (miR-122) is frequently suppressed in primary hepatocellular carcinomas (HCCs). In situ hybridization demonstrated that miR-122 is abundantly expressed in hepatocytes but barely detectable in primary human HCC...

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Hlavní autoři: Bai, Shoumei, Nasser, Mohd W., Wang, Bo, Hsu, Shu-Hao, Datta, Jharna, Kutay, Huban, Yadav, Arti, Nuovo, Gerard, Kumar, Pawan, Ghoshal, Kalpana
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
RNA-Mediated Regulation and Noncoding RNAs
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797273/
https://ncbi.nlm.nih.gov/pubmed/19726678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.016774
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